“From Bed to Bench and Back” (B3) is the concept tied to the PCCC and illustrates how the partnership operates. “Bed” symbolizes the daily contact with IPO-Porto regarding cancer patients’ real needs. These needs and problems felt by the patients drive research development at the two institutions that constitute the PCCC (Bench), with the objective to find solutions through clinical trials that seek to improve the care provided with the discovery of innovative treatments. This goes back to the patient (Back) who will participate in the clinical trials developed at the PCCC. It is a cyclical process that constantly searches for better treatments for cancer patients.

At the Porto Cancer Comprehensive Centre, collaborative research projects offering new realities and hopes for oncology have been developed:

2007 – 2012

Early detection of cancer, using new serological markers based on post-translational modifications of glycoproteins

IPO-Porto: Selection of samples of patients and immunohistochemistry analysis

IPATIMUP: Proteomic study of serological markers

2009 – 2015

Genetic study in patients with paraganglioma(s)

Objective: REsearch germinating mutations in a consecutive series of patients with paragangliomas so as to identify which are hereditary

IPO-Porto: Selecting patients, genetic counselling, conducting counter-analyses, genetic study of families, tracking carriers

IPATIMUP: Genetic study of each family’s first patient.

2010-2015

Biomarkers to evaluate therapeutic effectiveness on colorectal cancer*

Objective: research on somatic mutations that predict response to therapy directed towards the EGFR receptor in metastatic colorectal cancer

IPO-Porto: Molecular analysis of 400 patients in retrospective study and 100 patients in prospective study, for a total of 500 patients from IPO-Porto

IPATIMUP: Molecular analysis of 400 patients in retrospective study and 100 patients in prospective study, for a total of 500 patients from Hospital de São João

*Within the scope of the DoIT-Development and Operationalization of Translational Research project